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The trial enrolled 329 Chinese adult patients with diabesity who exhibited representative real-world metabolic characteristics: Mean age: approximately 42 years Mean HbA1c: 8.02% Mean BMI: 33.0 kg/m Mean body weight: 90.5 kg Mean disease duration: 1.8 years Participants were randomized 1:1 to receive: Mazdutide (69 mg dose escalation) Semaglutide (1 mg standard treatment regimen) The treatment duration was 32 weeks, with evaluation of both glycemic and weight-related metabolic endpoints
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This helps increase energy metabolism by improving how mitochondria convert nutrients into energy
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Data synthesis and statistical analysis To obtain the overall effect size, means and sd of after values in the NAC and control groups were analysed
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